Synonyms/Common Names/Related Substances:

• Ackerklee (German), beebread, biochanin A, cow clover, daidzein, equol, Fabaceae (family), formononetin, genistein, isoflavone, isoflavone clover extract (ICE), meadow clover, o-desmethylangolensin, O-DMA, phytoestrogen, Promensil®, purple clover, Rimostil®, Rotklee (German), trèfle des prés (French), trefoil, Trifolium pratense, Trinovin®, wild clover.

Clinical Bottom Line/Effectiveness

Brief Background:

• Red clover is a legume, which, like soy, contains phytoestrogens (plant-based compounds structurally similar to estradiol, capable of binding to estrogen receptors as agonists or antagonists). Red clover was traditionally used to treat asthma, pertussis, cancer, and gout. In modern times, isoflavone extracts of red clover are most often used to treat menopausal symptoms, as an alternative hormone replacement therapy, for hyperlipidemia, or to prevent osteoporosis.
• At this time, there is a lack of available high-quality human trials supporting the efficacy of red clover for any indication (1). Soy protein, another source of isoflavones, has been reported to significantly reduce serum lipid levels, but this benefit has not been demonstrated for red clover and may be due to the presence of other constituents in soy (e.g., saponins, pectins, essential fatty acids).

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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