Synonyms/Common Names/Related Substances:
- AHCC, Basidiomycota mushroom, functional food, Lentinula edodes.
Clinical Bottom Line/Effectiveness
Brief Background:
- Active hexose correlated compound (AHCC) is an alpha-glucan-rich dietary supplement extracted from the mycelia of Basidiomycota mushrooms, such as shiitake (Lentinula edodes), and contains a mix of oligosaccharides (around 74% of AHCC, about 20% being of the alpha-1,4-glucan type), amino acids, lipids, and minerals (1). AHCC is water-soluble, water-stable, and microcoated with candelilla wax to improve solubility in the intestines.
- AHCC is predominantly used for its purported ability to stimulate the immune system and as an adjuvant therapy to reduce the adverse side effects of chemotherapy. AHCC was developed in Japan in 1992, with several studies reporting a variety of therapeutic effects, including antioxidant and anticancer activity, prevention of the onset of diabetes, prevention of liver injury, and improvement of immune response.
- While initial research is promising, clinical evidence supporting the therapeutic application of AHCC in any human indication is lacking. Further research is required.
Dosing/Toxicology
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Precautions/Contraindications
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Interactions
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
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Mechanism of Action
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History
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Evidence Table
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Evidence Discussion
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Products Studied
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Author Information
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References
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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